We recommend that the CBP Senior Official Performing the Duties of the Commissioner designate an official or group to be responsible for implementing the requirements of the Synthetic Opioid Exposure Prevention and Training Act and: • issue a component-wide policy to the CBP workforce to safely handle potential synthetic opioids; • make personal protective equipment and opioid receptor antagonists, including naloxone, available and readily accessible to all personnel at risk of exposure to opioids; and • require initial and recurrent training for all at-risk personnel on the risk of opioid exposure and how to access and administer naloxone.